Detection of deep venous thrombosis with indium 111-labelled monoclonal antibody against tissue plasminogen activator
Identifieur interne : 000387 ( Main/Exploration ); précédent : 000386; suivant : 000388Detection of deep venous thrombosis with indium 111-labelled monoclonal antibody against tissue plasminogen activator
Auteurs : RBID : ISTEX:259_1991_Article_BF02285459.pdfEnglish descriptors
Abstract
The administration of a radiolabelled monoclonal antibody against tissue plasminogen activator allows detection of areas with increased fibrinolytic activity, i. e. those with an active thrombotic lesion. Eight patients with phlebographically verified deep venous thrombosis were examined. At the time of immunoscintigraphy study they were examined receiving anticoagulant therapy. Some 75–85 MBq indium 111-labelled antibody were injected, and scintigrams were obtained after 30 min and after 24 h. The precise site of the thrombus could not be visualized after 30 min due to high background activity, whereas after 24 h it was detectable in all patients. The thrombus/background ratios achieved are twice as high as those observed in a human antifibrin antibody study. These preliminary data suggest a high sensitivity of our t-PA-specific antibody for the detection of active deep venous thrombosis in man, and our antibody seems to offer theoretical advantages over both platelet and fibrin-specific antibodies.
DOI: 10.1007/BF02285459
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Eight patients with phlebographically verified deep venous thrombosis were examined. At the time of immunoscintigraphy study they were examined receiving anticoagulant therapy. Some 75–85 MBq indium 111-labelled antibody were injected, and scintigrams were obtained after 30 min and after 24 h. The precise site of the thrombus could not be visualized after 30 min due to high background activity, whereas after 24 h it was detectable in all patients. The thrombus/background ratios achieved are twice as high as those observed in a human antifibrin antibody study. These preliminary data suggest a high sensitivity of our t-PA-specific antibody for the detection of active deep venous thrombosis in man, and our antibody seems to offer theoretical advantages over both platelet and fibrin-specific antibodies.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="9c3defc3ef91ef15eaa081bd4fd385a377e234d7"><titleInfo lang="eng"><title>Detection of deep venous thrombosis with indium 111-labelled monoclonal antibody against tissue plasminogen activator</title></titleInfo><name type="personal"><namePart type="given">Niels</namePart><namePart type="family">Tromholt</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Clinical Physiology and Nuclear Medicine KF 4011, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark</affiliation></name><name type="personal"><namePart type="given">Birger</namePart><namePart type="family">Hesse</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Clinical Physiology and Nuclear Medicine KF 4011, Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen Ø, Denmark</affiliation></name><name type="personal"><namePart type="given">Ole</namePart><namePart type="family">Folkenborg</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>The Isotope Pharmacy, Copenhagen, </affiliation></name><name type="personal"><namePart type="given">Johan</namePart><namePart type="family">Selmer</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Novo Nordisk, Bagsværd, Denmark</affiliation></name><name type="personal"><namePart type="given">Nina Thrane</namePart><namePart type="family">Nielsen</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Radiology, Hillerod County Hospital, Denmark</affiliation></name><typeOfResource>text</typeOfResource><genre>Original article</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1990-12-28</dateCreated><dateValid encoding="w3cdtf">2005-11-30</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">The administration of a radiolabelled monoclonal antibody against tissue plasminogen activator allows detection of areas with increased fibrinolytic activity, i. e. those with an active thrombotic lesion. Eight patients with phlebographically verified deep venous thrombosis were examined. At the time of immunoscintigraphy study they were examined receiving anticoagulant therapy. Some 75–85 MBq indium 111-labelled antibody were injected, and scintigrams were obtained after 30 min and after 24 h. The precise site of the thrombus could not be visualized after 30 min due to high background activity, whereas after 24 h it was detectable in all patients. The thrombus/background ratios achieved are twice as high as those observed in a human antifibrin antibody study. These preliminary data suggest a high sensitivity of our t-PA-specific antibody for the detection of active deep venous thrombosis in man, and our antibody seems to offer theoretical advantages over both platelet and fibrin-specific antibodies.</abstract><subject lang="eng"><genre>Key words</genre><topic>Immunoscintigraphy</topic><topic>Tissue plasminogen activator</topic><topic>Radiolabelled antibody</topic><topic>Venous thrombosis</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1991</partNumber><partNumber>Volume: 18</partNumber><partNumber>Number: 5</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1991-05-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 12</identifier><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF02285459</identifier><identifier type="matrixNumber">Art4</identifier><identifier type="local">BF02285459</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>321</start><end>325</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1991</recordOrigin><recordIdentifier>259_1991_Article_BF02285459.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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